Targeting Androgen Receptor Function by MicroRNA in Prostate Cancer

摘要

Prostate cancer is the most commonly diagnosed and second most deadly cancer in North American men and the blockade of androgen action through the AR has been the cornerstone of systemic therapy of prostate cancer. The failure of AR receptor antagonists results in higher levels of AR protein which promotes the development of androgen-independent prostate cancer. Originally we proposed the utilization of micro (mi) RNAs to blockade the expression of AR in prostate carcinoma cells. We have identified a miRNAs that can repress the AR protein synthesis in prostate carcinoma cells. Our long-term goals are to identify naturally occurring miRNAs that have potential to block the activity of AR and to improvise their efficacy by rational designing to provide novel 'AR Antagonist miRNAs'.