NF-kB2/p52 Activation and Androgen Receptor Signaling in Prostate Cancer

摘要

The goal of this project is to characterize the role of NF- B2/p52 in the aberrant activation of AR signaling in castration-resistan prostate cancer. Our preliminary data demonstrate that NF- B2/p52 is expressed at high levels in prostate cancer and tha overexpression of NF- B2/p52 facilitates castration resistant prostate cancer progression by activation of AR signaling and rescue of cancer cells from apoptotic death induced by androgen deprivation. Our hypothesis is that NF- B2/p52 activates the AR and protects prostate cancer cells from apoptotic cell death induced by androgen deprivation therapy, leading to the development of castration resistance prostate cancer. The specific aims are: 1. To determine the role of p52 activation in androgen responsiveness and progression of castration resistant prostate cancer. 2. To determine the effect of expression o p52 on the development and progression of prostate cancer in a transgenic mouse model. 3. To determine the mechanisms o AR activation by p52.