Mechanical Tissue Resuscitation Treatment Reduces Brain Tissue Volume and Intracerebral Hemorrhage and Increases Blood Perfusion in a Traumatic Brain Injury Model in Swine

摘要

Each major war tends to have a 'signature injury' with traumatic brain injury (TBI) associated with the Iraq war (Operation Iraqi Freedom II and Operation Enduring Freedom) due to the high incidence of personnel injured by IED (improvised explosive devices). Based upon successful outcomes in a rat model, this study in swine examined the efficacy of application of either 50 or 100 mm Hg vacuum to a controlled cortical impact (focal injury). Based on MRI and histological analysis, 100 mm Hg applied immediately after injury and continued for 72 hours was more efficacious than 50 mm Hg in decreasing the volume of injured tissue and the volume of hemorrhage.