Repression of TSC2 Expression by miR-296 in Human Normal and Tumor Tissues

摘要

Tuberous sclerosis complex (TSC) genes are tumor suppressors and are ubiquitous and expressed in almost all human tissues. Loss or inactivation of TSC genes contributes to a broad spectrum of diseases, including multiorgan neoplasia, and virtually any part of the body can be affected. Loss of the wild type allele and second somatic mutations is the major molecular mechanism identified in some but not all TSC-associated tumors.