Oxime Pro-2-PAM Provides Minimal Protection Against the CNS Effects of the Nerve Agents Sarin, Cyclosarin, and VX in Guinea Pigs

摘要

Chemical warfare nerve agents and certain pesticides are organophosphorus compounds (OPs) that potently inhibit cholinesterases (ChEs), in particular acetylcholinesterase (AChE), an enzyme that hydrolyzes the cholinergic neurotransmitter acetylcholine (ACh) in the peripheral and central nervous system (CNS) (Taylor 2001).