STUDY OF THE ORGANIC ACIDS IN SERUM, URINE AND BLOOD DIALYSATE OF PATIENTS WITH UREMIA “QUALIFIED REQUESTORS MAY OBTAIM COPIES OF THIS REPORT FROM ASTIA”

摘要

The signs and symptoms of uremia appear to be related to the organic anions which accumulate and circulate in body fluids following renal insufficiency. In uremic patients these anions rise to 10-20 meq/L as compared to normal, which is 5. Fractionation of the anions reveal several hundred definitive compounds observed after counter-current fractionation and paper chromatography. These compounds are demonstrated by their ability to absorb ultraviolet light or to fluoresce. Compounds such as indoles, phenols, substituted hippuric acids have been identified. Some of the latter, such as o-hydroxybenzoylglycine have been isolated and absolutely identified from dialysis fluids obtained from uremic patients. Techniques have been established for measuring, isolating and identifying minute amounts of compound,