Search for Effective Chemical Vaccines Against Some Zoonoses. Communication IV. Experiences in Obtaining Chemical Anthrax Vaccines in Semi-Industrial Conditions (Izyskanie Effektivnykh Khimicheskikh Vaktsin Protiv Nekotorykh Zoonoz. Soobshchenie 4. Opyt Polucheniya Khimicheskoi Sibireyazvennoi Vaktsiny V Poluproizvodstvennykh Usloviyakh)

摘要

A possibility of obtaining chemical anthrax vaccine in semi-industrial conditions was investigated. Biosynthesis of the protective antigen, as well as other processes of anthrax metabolism were the same in 100-litre cultivators as in the 5-litre bottles. The immunological efficacy of the protective antigen obtained in the cultivators and bottles proved to be the same. Of all the methods used for sterilization of large volumes of the protective antigen (treatment with beta-propiolacton, merthiolate, formalin) the best results were obtained with formalin. Thus, the possibility of preparing chemical anthrax vaccine in semi-industrial conditions was established. (Author)