The Influence of Streptomycin on the Effectiveness of Experimental Immunization with Live Vaccines. Report II. Administration of Streptomycin During Immunization with Tularemia Vaccine

摘要

Conclusions: The administration of streptomycin in doses exceeding those usually used for the emergency prophylaxis of tularemia by 2 and 4 times (considering the weight of the animal) did not lower the resistance of white mice to subsequent infection during the carrying out of immunization with tularemia vaccine. For evaluating the immunogenicity of live tularemia vaccines in an experiment, it is possible to make use of the infection of white mice with vaccine tularemia strains. During this the administration of 5 mg of cortisone 4 hours prior to infection sharply increased the sensitivity of the white mice and created a very effective experimental model of tularemia infection. (Author)