A Study of Early Radiation-Induced Biological Changes as Indicators of Radiation Injury

摘要

The study is a part of a broad review of current research on the biological effects of radiation to explore the possibility of developing improved treatment measures. Prompt diagnosis of the radiation-induced injury is important in prognosis and the military use of these clinical judgements will determine the immediate future role of the soldier. The scope of the study included: the use of physical dosimetry; early clinical manifestations of radiation-induced emesis; radiation-induced cytological changes in the testes; urinary constituents as predictors of radiation injury; hematologic changes; serum iron levels as indicators of hematopoietic dysfunction or injury; etiocholanolone in estimating bone marrow granulocyte reserves; total protein-bound neutral hexoses in the plasma as related to radiation sensitivity; effects of radiation on detoxification enzymes, drug metabolism, and biochemical changes; and chromosome aberrations as indices of radiation injury. (Author)