The Effect of Chronic Hypercapnia on Oxygen Affinity and 2, 3 Diphosphoglycerate as Related to Submarine Exposure

摘要

The relationship between oxygen affinity and 2,3 diphosphoglycerate (2,3 DPG) in the red cell has been studied in chronic hypercapnia induced by prolonged exposure of guinea pigs to 15% CO2 in 21% O2. Red cell pH fell to a minimum after six hours of exposure and subsequently rose without reaching initial values after seven days of exposure. Both oxygen half-saturation pressure (P50) and the level of 2,3 DPG of the red cells followed the time course of the pH changes. However, both parameters required 24 hours to reach a minimum, following which they increased steadily and were not different from control values after seven days of exposure. (Author)