Treatment of Experimental Cerebral Edema

摘要

The edema associated with hemorrhagic cerebral lesions produced by focal freezing in subhuman primates (rhesus monkeys) was studied by quantitative chemical methods. This research involved measuring not only the hemispheric water, potassium, sodium, chloride, and iron, but also the uptake of I.V. administered Evans blue and iodinated I131 serium albumin. The effects of systemic hypothermia and of hypotension were studied. The conclusion was that this form of edema could be effectively treated by either method, but that the former was the more effective. Because the state of hypothermia was associated with moderate hypotension, and vice versa, the beneficial effects could not be attributed to either factor acing alone. The experimental model was compared to human disease, and therapeutic recommendations for clinical conditions were made. (Author)