Partial Characterization of Carbohydrate Residues of Serum Glycoproteins in Neoplastic Disease

摘要

The objective of this investigation was primarily to establish that the apparent increase in serum fucose levels in patients with malignant tumors is real and to obtain data as to its source. Carbohydrate residues (L-fucose, D-mannose, D-galactose) were estimated by borate ion-exchange chromatography after mild acid hydrolysis of serum proteins. Data are presented which confirm reported increases in levels of serum fucose in certain malignancies and indicate that these increases may be attributed to quantitative alterations in specific serum glycoproteins observed in the glycoprotein profile associated with cancer. Values for serum fucose levels in pathological and nonpathological sera obtained by various analytical methods are presented and discussed. (Author)