Treatment of 'Hymenolepis Nana' with Niclosamide, Mepacrine and Thiabendazole.

摘要

Sixty patients infected with Hymenolepis nana were treated with niclosamide (Yomesan), mepacrine (Atabrine), or thiabendazole (Mintezol). Twenty patients were included in each group. Fourteen other patients were given placebo starch and were included as a control group. Yomesan was given initially at a dosage of 60 mg/kg body weight, followed by 15 mg/kg body weight for six more days. Atabrine was given at the dosage of 15 mg/kg body weight for one day and Mintezol was given at the dosage of 25 mg/kg body weight twice daily for two days. At the end of two weeks, 17 patients (85 per cent) treated with Yomesan were ova-free compared to 12 patients (60 per cent) treated with Atabrine and four patients (20 per cent) treated with Mintezol. Five weeks after treatment the cure rates in the case of Yomesan had dropped to 14 patients (70 per cent), while in the cases of Atabrine and Mintezol it had dropped to three patients (15 per cent) and one patient (five per cent) respectively. There was no side reaction from Yomesan, while there were minimal gastro-intestinal disturbances from Atabrine and Mintezol. (Author)