Relation of Lichen Sclerosus et Atrophicus of the Vulva to Development of Carcinoma.

摘要

One hundred and seven patients with lichen sclerosus et atrophicus (LS/A) of the vulva were studied to determine the malignant potential of the LS/A. Five patients had coexisting invasive carcinoma of the vulva or perineum with the LS/A, and 1 patient had coexisting intraepithelial vulvar carcinoma on the clitoris. None of these, however, was known to have LS/A prior to the biopsy for carcinoma of the vulva. The high association of carcinoma and LS/A is probably a result of selection of 2 unusual lesions sent for consultation and evaluation. Squamous hyperplasia in the vulva occurred in association with LS/A in 37 (35%) patients, but only 6 patients had areas of dysplasia coexisting with LS/A. This study did not provide evidence of carcinoma arising from LS/A. Five of the 92 patients developed 6 malignant neoplasms in other sites, including carcinoma of the endometrium (3 patients), lung (1 patient), and simultaneous carcinomas of the colon and cervix (1 patient).