Inhibitory Action of Norepinephrine on the Induction of Tryptophan-2,3-Dioxygenase by Cortisol: Mediation by the Alpha-Receptor.

摘要

Induction of hepatic tryptophan-2,3-dioxygenase in rats by cortisol or corticosterone was inhibited on treatment with norepinephrine. The beta-adrenergic blockers showed a small potentiating effect of the norepinephrine-mediated inhibition. The alpha-adrenergic blockers significantly reversed this inhibition, suggesting that norepinephrine acts via the alpha-receptor in inhibition of the cortisol-mediated induction of this enzyme. (Author)