Resin Hemoperfusion: A Method of Removing Circulating Thyroid Hormones.

摘要

The ability of an extracorporeal hemoperfusion system employing neutral Amberlite resin to bind thyroid hormone and to decrease circulating levels of triiodothyronine (T3), throxine (T4), and free thyroxine (FT4) was evaluated in dogs made thyrotoxic by the intramuscular administration of thyroid hormone. After correction for hemodilution, the mean serum T3, T4 and FT4 decreased during 2 hours of resin hemoperfusion by 39%, 35% and 46% respectively. Hormonal clearance rates were calculated in two experiments and the estimated net hormone removed averaged 60.4 ug of T3 and 1990 ug of T4.