Preliminary Assessment of Relative Toxicity of Candidate Repellent Cyclohexamethylene Carbamide.

摘要

Preliminary assessment of the relative toxicity of a proposed insect repellent cyclohexamethylene carbamide, was conducted using laboratory animals. Technical grade compound produced primary irritation of the intact and abraded skin of rabbits. However, single application of a 25 percent solution in ethanol did not produce irritation. Data obtained from 21-day continuous application of 1 percent ethanol solutions to rabbit skin, and skin sensitization studies in guinea pigs failed to indicate an unusual degree of hazard associated with its use as a topical repellent. Studies of percutaneous penetration using 14C-ring labeled compound indicated that this material is readily absorbed through the skin of rabbits and almost totally excreted in the urine. Virtually all topically administered label was recovered either in urine or at the application site, indicating little hazard from cumulative deposition. (Author)