Reduction in Baroreflex Cardiovascular Responses Due to Venous Infusion in the Rabbit.

摘要

Reflex bradycardia and depression of mean arterial blood pressure (MAP) were studied during left aortic nerve (LAN) stimulation before and after volume infusion in the anesthetized rabbit. Step increases in mean right atrial pressure (MRAP) to 10 mm Hg did not result in a significant change in heart rate or MAP. After volume loading, responses to LAN stimulation were not as great and the degree of attenuation was proportional to the level of increased MRAP. A change in responsiveness was observed after elevation of MRAP by only 1 mm Hg, corresponding to less than a 10% increase in average calculated blood volume. After an increase in MRAP of 10 mm Hg, peak responses were attenuated by 44% (heart rate) and 52% (MAP), and the initial slopes (rate of change) were reduced by 46% (heart rate) and 66% (MAP). Comparison of the responses after infusion with blood and dextran solutions indicated that hemodilution was an unlikely explanation for the attenuation of the reflex responses. Total arterial baroreceptor denervation (ABD) abolished the volume-related attenuation of the cardiovascular responses, whereas attenuation was still present following bilateral aortic nerve section or vagotomy. It thus appears that the carotid sinus responds to changes in blood volume and influences the reflex cardiovascular responses to afferent stimulation of the LAN.