Prevention of Hemoglobinuric Nephrosis.

摘要

Intravenous injection into rabbits, baboons and humans of large volumes of hemoglobin (in frozen-thawed blood) caused hemoglobinuria without any evidence of renal disturbance, nor was there evidence of clinically significant disseminated intravascular coagulopathy (DIC). The rate of urinary hemoglobin excretion was determined. In the baboon, the simultaneous injection of dextran solution did not modify the rate of hemoglobin excretion. In one patient with nocturnal hemoglobinuria, infusion of dextran solution was associated with decreased hemoglobin excretion. (Author)