Subhuman Primate Model for the Study of Infection Induced by 'Klebsiella pneumoniae'.

摘要

Squirrel monkeys were instilled intratracheally with 700 Klebsiella pneumoniae organisms and developed lobar pneumonia in about 24 h. Characteristic clinical findings were fever, anorexia, and coughing. Laboratory findings included leukocytosis or leukopenia, with the latter more prominent in ultimately fatal infections; bacteremia and shedding of bacteria into the pharynx. Infected monkeys showed increased plasma lysozyme activity as well as increased plasma ceruloplasmin, haptoglobin and alpha sub 1-antitrypsin. MORTALITY RATE WAS 60%; mean time to death was 50.5 h. Pathologically, the disease spread by means of the pores of Cohn and other pathways that generally did not involve airways as a means of dissemination until about 30 h. The squirrel monkey seems to be a better model for human respiratory K. pneumoniae infection than does the rat or mouse. (Author)