Urinary Molecular Determinants for the Prediction of Ischemic Anoxic Stress Pathology: Evaluation of Lipid Peroxides, Phenolic Acids and Generated Free Radical Compounds as Bioindicators of Stress.

摘要

In preliminary studies in which a small number of test subjects were used, the 24-hr urinary excretion of phenolic acids, lipid peroxides and generated free radicals when plotted in a three-dimensional manner appeared to be a bioindicator of the effects of pathological stress. This methodology was tested with larger populations of control, acceleration stressed, and coronary artery diseased subjects to obtain statistically reliable data. Results showed large individual variations in excretion of three parameters within each test group, as well as for individual subjects tested on different days. Consequently, overlapping of calculated mean values and standard error of the means, for the test groups, invalidates use of GFR-lipid peroxide-phenolic acid three-dimensional plot as a noninvasive bioindicator of stress. (Author)