Lower Prediagnostic Serum 25-Hydroxyvitamin D Concentration Is Associated With Higher Risk of Insulin-requiring Diabetes: A Nested Case- Control Study.

摘要

Aims/hypothesis Low serum 25-hydroxyvitamin D 25 (OH)D concentration may increase risk of insulinrequiring diabetes. Methods A nested case control study was performed using serum collected during 2002 2008 from military service members. One thousand subjects subsequently developed insulin- requiring diabetes. A healthy control was individually matched to each case on blood-draw date ( 2 days), age ( 3 months), length of service ( 30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression.