Early Breast Lesion Typing With Hyperpolarized Choline, Benign Or Malignant.

摘要

This work is focused on developing a breast cancer biomarker utilizing magnetic resonance spectroscopy/imaging and hyperpolarization. I have initiated and completed most of the elements in the first part of the project which consist of developing the equipment and the biomarker agent. Task 2-4 required the completion of Task 1. The most significant achievement is the completion of the required equipment and initial testing. We have developed a fully functional parahydrogen induced polarization (PHIP) instrument and verified the functionality with a PHIP agent. Task 1 a the development of a fixed field magnet was abandoned due to construction difficulties and better alternative solution to allowing us to generate a stable homogeneous magnetic field with a current controlled solenoid. This project was extended 6 months due to delivery problems for the required transgenic mice. We are on schedule to begin and complete Task 2-4, the in vivo an in vitro proof of concept testing of the accumulation of 15N-Iabeled choline analog in breast cancer cells by hyperpolarized 15N.