Regional Brain Levels of N-Acetyl-Aspartyl-Glutamate: The Effect of Kindled Seizures

摘要

Rats were subjected to daily amygdaloid-kindling stimulation and sacrificed 48h after their fifth stage-5 kindled seizure. Regional brain dissection was performed and the regions assayed for levels of N-acetyl-aspartyl-glutamate, an endogenous dipeptide specific to the brain and a putative excitatory neurotransmitter. Kindling produced significant increases in this dipeptide in the entorhinal cortex. (Reprint).