Nonmutagenic Response in the Ames Test of an Extract of Pyrotechnically Disseminated Terephthalic Acid

摘要

Residue from pyrotechnically disseminated terephthalic acid (100 mg) was extracted for 24 hr with 25 mL of methylene chloride. This extractant was replaced with 10 mL of acetone by evaporation, and five concentrations of this stock solution (SS) at one log intervals were tested for mutagenicity using the Ames Salmonella strains TA97, TA98, TA100 and TA102. Both metabolically activated (aroclor 1254 induced rat liver S9) and nonactivated plates were tested. The results were negative. The SS was concentrated to one-tenth of its volume by evaporation, and the test was run again using this higher concentration. Cytotoxicity was seen in the higher concentrations in strains TA98, TA100, and TA102 on the activated plates; however, the results were negative. Keywords: Metabolic activation; Mutagenicity; Cytogenicity.