Regulation of Glutathione in a Rat Diploid Hepatic Epithelial Cell Line

摘要

If cells were to elect a 'most valuable player' from among their cytoplasmicconstituents, glutathione (GSH) must surely win. Aside from being the most prevalent cellular thiol, it performs feats beyond the grandest expectations for a simple three amino acid peptide. Glutathione has been extensively reviewed and it is not my task to do so again. However, it will be the purpose of this report to investigate some of the mechanisms by which cells produce and maintain their pool of GSH. Toward that end, to follow is a brief outline of the synthesis and metabolism of glutathione and its utility in cellular ecology. (JES)