Structural Comparison of the Potent Antimuscarinic Agent Azaprophen Hydrochloridewith Aprophen Hydrochloride and Structurally Related Antimuscarinic Agents

摘要

A comparison of the crystalline structure of the potent azaprophen with thecrystalline structures of aprophen and four other structurally related antimuscarinic agents reveals the potential for an ionic interaction of the cationic nitrogen atom and the carbonyl oxygen atom with the muscarinic receptor and an aromatic interaction with a phenyl group, 6-Methyl-6-azabicyclo3.2.1octan-3a-ol 2,2-diphenylpropionate hydrochloride (azaprophen hydrochloride).