Pharmacokinetic Models for the Elimination of Drinking Water Contaminants fromthe Body

摘要

Humans are exposed to a variety of chemicals in drinking water. These chemicalsor their toxic metabolites could elicit adverse biological effects in target tissues if present at sufficient concentrations and exposure durations. Understanding the metabolism and pharmacokinetics of these chemicals thus can provide a better evaluation of biological effects associated with environmental exposure. In this research project, an attempt is made to understand the pharmacokinetic behaviour of representative chemicals and to identify those models most suitable in estimating the time period required to excrete drinking water contaminants at concentrations specified by One-day, Ten-day, Longer-term, and lifetime exposure Health Advisories. In addition, available pharmacokinetics models are critically evaluated for their strengths and weaknesses in achieving the objective specified.