2,3,7,8-Tetrachlorodibenzo-p-dioxin Pretreatment of Female Mice Altered TissueDistribution but not Hepatic Metabolism of a Subsequent Dose

摘要

Concern over environmental contamination with 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) stimulated research of its toxic actions and underlying molecular events. Various epithelia, epithelial-derived tissues such as liver, and the immune system were identified as major target tissues. A toxic mechanism based upon interaction of TCDD with the Ah receptor and subsequent expression of a pleiotropic response provided an explanation for many reported phenomena. In light of the tissue and subcellular specificity of TCDD action, tissue distribution of a given dose likely has substantial effects on patterns of tissue damage. Further, chronic toxicity of repeated low doses may be influenced by factors which increase or decrease TCDD concentrations to which particular cell types are exposed. Reprints. (JES)