Immediate Hypertensive Response to Fluid Percussion Brain Injury May be Relatedto Intracerebral Hemorrhage and Hypothalamic Damage

摘要

Fluid percussion brain injury is associated with an immediate rise in meanarterial pressure (MAP). However, the cerebral morphologic basis for this response is still not clear. Thirty-four anesthetized rats were injured using a lateral craniotomy preparation. In 19 rats, impact level was set at 1.73 atm, and impact duration was kept at 25 msec to examine the relationship between postinjury hypertensive response and cerebral lesions. MAP was monitored for 1 hour after impact. Fluid percussion produced an increase in MAP from 99 to 134 mm