Synthetic Conversion of Bryostatin 2 to Bryostatin 1 and Related Bryopyrans

摘要

The marine Bryozoan Bugula neritina has been found to contain a series ofbiologically and chemically exciting constituents now known as the bryostatins. Other interesting biosynthetic products of the Phylum Bryozoa such as the beta-lactam-bearing chartellines have recently been isolated from Chartella papyracea. Bryostatin has been found to profoundly affect protein kinase C at picomolar concentrations. Uniquely among protein kinase C modulators, bryostatin 1 activates protein kinase C in vitro, antagonizes phorbol ester responses in many biological systems, and is deficient in tumor promoting activity. Bryostatin 1 has powerful immunopotentiating activities.