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Recognition of All Four Base Pairs of Duplex DNA by Triple Helix Formation. Design of Pyrimidine Specific Bases.

机译：通过三螺旋形成识别所有四个碱基对的双链DNa。嘧啶特异性碱基的设计。

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The novel base 4-(3-benzamido)phenylimidazole was designed, synthesized and incorporated within a pyrimidine oligonucleotide and shown to recognize pyrimidine purine base pairs over purine pyrimidine base pairs. Such specificity allows binding by triple helix formation at an 18 base pairs site in simian virus 40 DNA containing all four base pairs at physiologically relevant conditions.

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作者
Griffin, L. C.; Kiessling, L. L.; Dervan, P. B.;
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年度 1991
页码 1-22
总页数 22
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Deoxyribonucleic acids; Molecular biology; Pyrimidines; Nucleic acid heteroduplexes; Organic chemistry; Base sequence;

机译：脱氧核糖核酸;分子生物学;嘧啶;核酸异源双链;有机化学;碱基序列;

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专利

1. Sequence-specific recognition of the major groove of DNA by oligodeoxynucleotides via triple helix formation. Footprinting studies [J] . Claude Hélène, Jean-Christophe Fran?ois, Tula Saison-Behmoaras Nucleic acids research . 1988,第24期

机译：寡脱氧核苷酸通过三重螺旋形成对DNA主沟的序列特异性识别。足迹研究
2. STRONG, SPECIFIC, MONODENTATE G-C BASE PAIR RECOGNITION BY N-7-INOSINE DERIVATIVES IN THE PYRIMIDINE-CENTER-DOT-PURINE-PYRIMIDINE TRIPLE-HELICAL BINDING MOTIF [J] . Marfurt J. Parel SP. Leumann CJ. Nucleic Acids Research . 1997,第10期

机译：嘧啶-中心-点-嘌呤-嘧啶三螺旋结合基中N-7-肌苷衍生物对强特异性单链G-C碱基的识别
3. Strong, specific, monodentate G-C base pair recognition by N7-inosine derivatives in the pyrimidine?purine-pyrimidine triple-helical binding motif [J] . Christian J. Leumann, Judith Marfurt, Serge P. Parel Nucleic acids research . 1997,第10期

机译：在嘧啶-嘌呤-嘧啶三螺旋结合基序中被N7-肌苷衍生物强烈，特异性，单齿G-C碱基对识别
4. Conversion Of Helix-turn-helix Motif Sequence-specific DNA Binding Proteins Into Site-specific DNA Cleavage Agents [C] . Ebright R.H., Ebright Y.W., Pendergrast P.S., Engineering in Medicine and Biology Society, 1990., Proceedings of the Twelfth Annual International Conference of the IEEE . 1990

机译：螺旋转螺旋基序序列特定的DNA结合蛋白到位点特异性DNA裂解剂的转换。
5. Recognition of double helical DNA by purine oligonucleotides via triple helix formation. [D] . Beal, Peter Andrew. 1993

机译：嘌呤寡核苷酸通过三重螺旋形成识别双螺旋DNA。
6. Elucidation of the sequence-specific third-strand recognition of four Watson-Crick base pairs in a pyrimidine triple-helix motif: T.AT C.GC T.CG and G.TA. [O] . K Yoon, C A Hobbs, J Koch, 1992

机译：阐明了嘧啶三螺旋基序中的四个Watson-Crick碱基对的序列特异性第三链识别：T.ATC.GCT.CG和G.TA.
7. Elucidation of the sequence-specific third-strand recognition of four Watson-Crick base pairs in a pyrimidine triple-helix motif: T.AT, C.GC, T.CG, and G.TA. [O] . Yoon, K, Hobbs, C A, Koch, J, 1992

机译：阐明了嘧啶三螺旋基序中的四个Watson-Crick碱基对的序列特异性第三链识别：T.AT，C.GC，T.CG和G.TA.

Recognition of All Four Base Pairs of Duplex DNA by Triple Helix Formation. Design of Pyrimidine Specific Bases.

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