Passive Immunization Protects Against Sporozoites of Plasmodium yoellii andPlasmodium vivax but Active Immunization Does Not; Reactivity to Specific, Discrete Epitopes Appears Crucial

摘要

Monoclonal antibodies which bind to epitopes on the CS proteins of Plasmodiumyoelii and P. vivax can provide protect against sporozoite challenge when used as passive immunizing agents. Polyclonal antibodies raised against subunits of the CS protein containing the same epitopes do not. These studies suggest that very precise design of the immunogen is required to induce a protective polyclonal response.... Malaria, Circumsporozoite protein, Antibody, Epitope, Plasmodium.