Radioprotection of Hematopoietic Tissues in Mice by Lipoic Acid

摘要

Lipoic acid is a lipophilic antioxidant that participates in many enzymaticreactions and is used clinically to treat mushroom poisoning and metal toxicity. In this report the protective effect of lipoic acid (oxidized form) against radiation injury to hematopoietic tissues in mice was assessed by the endogenous and exogenous spleen colony assays and survival (LD50/30) assay. Intraperitoneal administration of lipoic acid at a nonlethal concentration of 200 mg/kg body wt, 30 min before irradiation increased the LD5O/30 from 8.67 to 10.93 Gy in male CD2F, mice. Following a 9-Gy irradiation, the yield of endogenous spleen colony-