Scientific and Technical Support Services. Toxicity of Microbial Metabolites of 2,4,6-Trinitrotoluene (TNT).

摘要

A review of the available literature on the known microbial metabolites of the explosive TNT has been carried out. Of the nine metabolites that have been identified and characterized in the reductive biotransformation pathway, only five acute toxicity studies have been reported on 2-amino-4,6- dinitrotoluene and 4-amino-2,6-dinitrotoluene. The results indicate that they are not acutely toxic in rats and mice. The Ames Salmonella bioassay was the only other study reported by three different groups of investigators. Only seven of the nine metabolites were tested: they were 2-hydroxylamino-4,6- dinitrotoluene, 2-amino-4,6-dinitrotoluene, 4-hydroxylamino- 2,6-dinitrotoluene, 4-amino-2,6-dinitrotoluene, 2,4,-diamino-6nitrotoluene, 4,4',6,6'-tetranitro-2, 2'-azoxytoluene and 2,2',6,6'-tetranitro- 4,4'azoxytoluene. Anomalous results were found and reported by all workers using this assay. For the ultimate determination of NOEL/NOAEL values to be made, numerous further studies need to be carried out, and recommendations for such studies have been made. NOEL/NOAEL, TNT, Metabolites, Microbial, Toxicity RA III.