Mechanisms of Tumor Necrosis Factor/Cachectin (TNFalpha)-Induced PulmonaryVascular Endothelial Injury

摘要

Diverse forms of severe military injuries can all lead to multiple organ failure(MOF). Prominent components to this life-threatening state include systemic vascular collapse, disseminated intravascular coagulation, and the Adult Respiratory Distress Syndrome (ARDS). One common element to these complications is the presence of endothelial cell (EC) injury or dysfunction. Two candidate mediators of pulmonary vascular EC injury and ARDS include the endogenous mediator tumor necrosis factor-a (TNF-a) and the exogenous factor, bacterial