Risk of Recurrence Following Breast-Conserving Therapy for Ductal Carcinoma In Situ.

摘要

The predoctoral fellowship has provided support for the training of Laurel Habel in the conduct of epidemiologic studies of breast cancer utilizing a variety of designs and analytic methods. Ms. Habel completed an analysis on the risk of contralateral breast cancer following breast cancer in situ (CIS). A cohort of 1929 women diagnosed with a first primary ductal or lobular carcinoma in situ between 1974 and 1993 in western Washington was followed for contralateral breast cancer through December 1993. After accounting for the estimated proportion of women treated with prophylactic mastectomy, rates of contralateral breast cancer were compared to population rates of first primary breast cancer using Poisson regression to adjust for age and calendar year. Rates of invasive cancer in the contralateral breast following CIS were two to three times higher than population rates and did not differ substantially by type of the initial CIS. Progress was also made on three other breast cancer projects. Other training during the fellowship period included participation in cancer reading and working groups and presentation of study results at a scientific meeting. During the fellowship period, Ms. Habel gained valuable skills and experience for a career in breast cancer epidemiology.