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Molecular Therapy. Nucleic Acids

【机译】：分子疗法。核酸

ISSN：-
出版周期：Monthly
语言：English

起始发布年份：2012
出版者：New York, NY : Nature Pub. Group
出版地：United States

NLM刊名缩写：Mol Ther Nucleic Acids

数据库引入：PubMed: v1, 2012-, PMC

MeSH词表主题词：Genetic Therapy; Molecular Biology; Nucleic Acids*

备注：Official journal of: American Society of Gene & Cell Therapy.展开▼

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1.Antithrombotic Effect of shRNA Target F12 Mediated by Adeno-Associated Virus

机译：腺相关病毒介导的shRNA靶标F12的抗血栓形成作用
- 作者：Fanfan Li;Xiao Yang;Jie Liu;Kuangyi Shu;Chenfang Shen;Tao Chen;Wei Yang;Shanshan Li;Xiaoou Wang;Minghua Jiang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
2.The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers

机译：MicroRNA-873在KRAS驱动的癌症进展中的调节作用。
- 作者：Hamada A. Mokhlis;Recep Bayraktar;Nashwa N. Kabil;Ayse Caner;Nermin Kahraman;Cristian Rodriguez-Aguayo;Erika P. Zambalde;Jianting Sheng;Kübra Karagoz;Pinar Kanlikilicer;Abdel Aziz H. Abdel Aziz;Tamer M. Abdelghany;Ahmed A. Ashour;Stephen Wong;Michael L. Gatza;George A. Calin;Gabriel Lopez-Berestein;Bulent Ozpolat
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- KRAS oncogene non-coding RNA microRNA ncRNA miR-873 proliferation invasion gene regulation tumorigenesis gene silencing therapy nanoparticles pancreatic cancer liposomes breast cancer triple-negative breast cancer;
3.Efficient Knockdown and Lack of Passenger Strand Activity by Dicer-Independent shRNAs Expressed from Pol II-Driven MicroRNA Scaffolds

机译：由Pol II驱动的MicroRNA支架表达的独立于切酶的shRNA的有效敲低和缺乏乘客链活性。
- 作者：Erik Kaadt;Sidsel Alsing;Claudia R. Cecchi;Christian Kroun Damgaard;Thomas J. Corydon;Lars Aagaard
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- RNAi Dicer-independent shRNA miR-451 miR-324 agoshRNA agshRNA passenger strand activity Drosha U1 promoter Pol-II driven miRNA scaffold;
4.DNA Aptamers Targeting BACE1 Reduce Amyloid Levels and Rescue Neuronal Deficiency in Cultured Cells

机译：靶向BACE1的DNA适体减少淀粉样蛋白水平并挽救培养细胞中的神经元缺陷。
- 作者：Jun Xiang;Wen Zhang;Xiao-Fang Cai;Min Cai;Zhong-Hai Yu;Feng Yang;Wen Zhu;Xiang-Ting Li;Ting Wu;Jing-Si Zhang;Ding-Fang Cai
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- Alzheimer’s disease amyloid BACE1 aptamer SELEX;
5.Posttranscriptional Regulation of 14q32 MicroRNAs by the CIRBP and HADHB during Vascular Regeneration after Ischemia

机译：缺血后血管再生过程中CIRBP和HADHB对14q32 MicroRNA的转录后调控
- 作者：Angela Downie Ruiz Velasco;Sabine M.J. Welten;Eveline A.C. Goossens;Paul H.A. Quax;Juri Rappsilber;Gracjan Michlewski;A. Yaël Nossent
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA 14q32 microRNA cluster miR-329 miR-495 HADHB CIRBP RNA binding proteins ischemia hindlimb ischemia model;
6.Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor

机译：通过异唾液酸糖蛋白受体的异位表达将GalNAc缀合的剪接转换ASO传递到非肝细胞。
- 作者：Juergen Scharner;Sabrina Qi;Frank Rigo;C. Frank Bennett;Adrian R. Krainer
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- ASGR asialoglycoprotein receptor ASO GalNAc antisense oligonucleotide splice switching xenograft receptor-mediated endocytosis ASO delivery;
7.Nucleotide Modification Alters MicroRNA-Dependent Silencing of MicroRNA Switches

机译：核苷酸修饰改变MicroRNA开关的依赖MicroRNA的沉默。
- 作者：John Lockhart;John Canfield;Ezinne Francess Mong;Jeffrey VanWye;Hana Totary-Jain
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- post-transcriptional regulation synthetic biology mRNA therapy non-viral gene delivery;
8.Genome-Editing Technologies: Concept Pros and Cons of Various Genome-Editing Techniques and Bioethical Concerns for Clinical Application

机译：基因组编辑技术：各种基因组编辑技术的概念优缺点和临床应用中的生物伦理问题
- 作者：Sikandar Hayat Khan
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- transcription activator-like effector nucleases TALENs zinc-finger nucleases ZFNs RNAi CRISPR/Cas9 technology;
9.Optimizing Synthetic miRNA Minigene Architecture for Efficient miRNA Hairpin Concatenation and Multi-target Gene Knockdown

机译：优化合成miRNA Minigene结构以实现有效的miRNA发夹级联和多靶基因敲低
- 作者：Francis Rousset;Patrick Salmon;Simon Bredl;Ophélie Cherpin;Marta Coelho;Renier Myburgh;Marco Alessandrini;Michael Perny;Marta Roccio;Roberto F. Speck;Pascal Senn;Karl Heinz Krause
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- siRNA miRNA synthetic miRNA minigene miRNA hairpins concatenation multi-target gene knockdown CCR5 NOX3 hematopoietic stem cells cochlea lentivector transduction;
10.MicroRNA-145 Regulates Pathological Retinal Angiogenesis by Suppression of TMOD3

机译：MicroRNA-145通过抑制TMOD3调节病理性视网膜血管生成。
- 作者：Chi-Hsiu Liu;Zhongxiao Wang;Shuo Huang;Ye Sun;Jing Chen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- angiogenesis endothelial cell microRNA miR-145 neovascularization retinopathy Tmod3;
11.Viral Vector-Based Delivery of CRISPR/Cas9 and Donor DNA for Homology-Directed Repair in an In Vitro Model for Canine Hemophilia B

机译：基于病毒载体的CRISPR / Cas9和供体DNA的递送用于在犬B型血友病的体外模型中进行同源性修复
- 作者：Jian Gao;Thorsten Bergmann;Wenli Zhang;Maren Schiwon;Eric Ehrke-Schulz;Anja Ehrhardt
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- hemophilia B gene therapy homology directed repair CRISPR/Cas9 HCAdV5 ssAAV2 single vector;
12.Rapidly Neutralizable and Highly Anticoagulant Thrombin-Binding DNA Aptamer Discovered by MACE SELEX

机译：MACE SELEX发现的可快速中和和高度抗凝的凝血酶结合DNA适体
- 作者：Koji Wakui;Toru Yoshitomi;Akane Yamaguchi;Maho Tsuchida;Shingo Saito;Masami Shibukawa;Hitoshi Furusho;Keitaro Yoshimoto
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- aptamer anticoagulant thrombin SELEX antidote toehold-mediated strand displacement capillary electrophoresis;
13.The Attenuation of Trophoblast Invasion Caused by the Downregulation of EZH2 Is Involved in the Pathogenesis of Human Recurrent Miscarriage

机译：EZH2的下调引起的滋养细胞侵袭的减弱与人类反复流产的发病机制有关。
- 作者：Shijian Lv;Na Wang;Hong Lv;Jieqiong Yang;Jianwei Liu;Wei-Ping Li;Cong Zhang;Zi-Jiang Chen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- EZH2 H3K27me3 trophoblast recurrent miscarriages EMT CDX1;
14.Delivery of Cell-Specific Aptamers to the Arterial Wall with an Occlusion Perfusion Catheter

机译：用闭塞灌注导管将细胞特异性适体递送到动脉壁
- 作者：Ofonime Udofot;Li-Hsien Lin;William H. Thiel;Megan Erwin;Emily Turner;Francis J. Miller Jr.;Paloma H. Giangrande;Saami K. Yazdani
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- Biodrug neointima cell-targeted aptamer local liquid delivery pre-clinical ex vivo perfusion catheter;
15.Generation of Genetically Stable Human Direct-Conversion-Derived Neural Stem Cells Using Quantity Control of Proto-oncogene Expression

机译：利用原癌基因表达的数量控制产生遗传稳定的人类直接转化衍生的神经干细胞
- 作者：Kwon Daekee;Han Mi-Jung;Ji Minjun;Ahn Hee-Jin;Seo Kwang-Won;Kang Kyung-Sun
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- c-Myc direct conversion direct-conversion-derived neural stem cells MOI p53;
16.Modeling the Kinetics of Lipid-Nanoparticle- Mediated Delivery of Multiple siRNAs to Evaluate the Effect on Competition for Ago2

机译：建模脂质纳米颗粒介导的多个siRNA的动力学以评估对Ago2竞争的影响。
- 作者：Radu Mihaila;Dipali Ruhela;Beverly Galinski;Ananda Card;Mark Cancilla;Timothy Shadel;Jing Kang;Samnang Tep;Jie Wei;R. Matthew Haas;Jeremy Caldwell;W. Michael Flanagan;Nelly Kuklin;Elena Cherkaev;Brandon Ason
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- RNA interference siRNA lipid nanoparticles combination therapy competition mathematical modeling;
17.Co-assembled Ca2+ Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery

机译：共组装的Ca2 +海藻酸钠-硫酸盐纳米粒子用于细胞内质粒DNA的传递
- 作者：Matan Goldshtein;Stav Shamir;Ekaterina Vinogradov;Alon Monsonego;Smadar Cohen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- polymeric nanoparticles plasmid DNA gene therapy calcium alginate sulfate;
18.miR-10a-5p Promotes Chondrocyte Apoptosis in Osteoarthritis by Targeting HOXA1

机译：miR-10a-5p通过靶向HOXA1促进骨关节炎中的软骨细胞凋亡
- 作者：Yan Ma;Yizheng Wu;Junxin Chen;Kangmao Huang;Bin Ji;Zhijun Chen;Qiang Wang;Jianjun Ma;Shuying Shen;Jianfeng Zhang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- osteoarthritis microRNA apoptosis homeobox protein HOXA1 miR-10a-5p;
19.Human Novel MicroRNA Seq-915_x4024 in Keratinocytes Contributes to Skin Regeneration by Suppressing Scar Formation

机译：角质形成细胞中的人类新型MicroRNA Seq-915_x4024通过抑制瘢痕形成有助于皮肤再生
- 作者：Feng Zhao;Hongxin Lang;Zhe Wang;Tao Zhang;Dianbao Zhang;Rui Wang;Xuewen Lin;Xiaoyu Liu;Ping Shi;Xining Pang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA skin regeneration keratinocytes wound healing scar formation;
20.miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma

机译：miR-125b上调miR-34a并顺序激活多发性骨髓瘤的应激适应和细胞死亡机制
- 作者：Gabriella Misso;Mayra Rachele Zarone;Angela Lombardi;Anna Grimaldi;Alessia Maria Cossu;Carmela Ferri;Margherita Russo;Daniela Cristina Vuoso;Amalia Luce;Hiromichi Kawasaki;Maria Teresa Di Martino;Antonella Virgilio;Agostino Festa;Aldo Galeone;Giuseppe De Rosa;Carlo Irace;Massimo Donadelli;Alois Necas;Evzen Amler;Pierosandro Tagliaferri;Pierfrancesco Tassone;Michele Caraglia
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-125b multiple myeloma apoptosis autophagy senescence miRNome miRNA therapeutics miR-34a next generation sequencing signal transduction;
21.AntagomiR-103 and -107 Treatment Affects Cardiac Function and Metabolism

机译：AntagomiR-103和-107治疗会影响心脏功能和代谢
- 作者：Monika Rech;Annika R. Kuhn;Joost Lumens;Paolo Carai;Rick van Leeuwen;Wouter Verhesen;Robin Verjans;Julie Lecomte;Yilin Liu;Joost J.F.P. Luiken;Ronny Mohren;Berta Cillero-Pastor;Stephane Heymans;Kèvin Knoops;Marc van Bilsen;Blanche Schroen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- Cardiomyocyte cardiac microRNA miR-103 miR-107 antagomiR mitochondria metabolism mass spectrometry electron microscopy;
22.Human Amniotic Epithelial Cell-Derived Exosomes Restore Ovarian Function by Transferring MicroRNAs against Apoptosis

机译：人羊膜上皮细胞衍生的外泌体通过转移抗凋亡的MicroRNA恢复卵巢功能。
- 作者：Qiuwan Zhang;Junyan Sun;Yating Huang;Shixia Bu;Ying Guo;Tingting Gu;Boning Li;Chunhui Wang;Dongmei Lai
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- premature ovarian failure human amniotic epithelial cells exosomes ovarian function apoptosis microRNAs;
23.Simultaneous Suppression of Multiple Programmed Cell Death Pathways by miRNA-105 in Cardiac Ischemic Injury

机译：miRNA-105在心肌缺血性损伤中同时抑制多种程序性细胞死亡途径
- 作者：Sunhye Shin;Jung-Won Choi;Hanbyeol Moon;Chang Youn Lee;Jun-Hee Park;Jiyun Lee;Hyang-Hee Seo;Gyoonhee Han;Soyeon Lim;Seahyoung Lee;Sang Woo Kim;Ki-Chul Hwang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- apoptosis ischemic heart microRNA-105 necroptosis programmed cell death;
24.Modulation of the IL-6-Signaling Pathway in Liver Cells by miRNAs Targeting gp130 JAK1 and/or STAT3

机译：靶向gp130JAK1和/或STAT3的miRNA对肝细胞中IL-6信号通路的调节
- 作者：Florence A. Servais;Mélanie Kirchmeyer;Matthias Hamdorf;Nadège W.E. Minoungou;Stefan Rose-John;Stephanie Kreis;Claude Haan;Iris Behrmann
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNAs signal transduction interleukin-6 gp130 cytokine JAK1 STAT3 cancer inflammation liver;
25.Hypermethylation of miR-205-5p by IR Governs Aggressiveness and Metastasis via Regulating Bcl-w and Src

机译：IR调节miR-205-5p的超甲基化可通过调节Bcl-w和Src来控制侵略性和转移。
- 作者：Eun Sook Kim;Jae Yeon Choi;Su Jin Hwang;In Hwa Bae
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- radioresistance Bcl-w miR-205-5p hypermethylation metastasis;
26.Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway

机译：环状RNA circCHFR通过miR-370 / FOXO1 / Cyclin D1途径促进血管平滑肌的增殖和迁移
- 作者：Lei Yang;Fan Yang;Haikang Zhao;Maode Wang;Yuelin Zhang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- atherosclerosis circular RNA circCHFR vascular smooth muscle cells FOXO1 CCND1;
27.Knockdown of USF1 Inhibits the Vasculogenic Mimicry of Glioma Cells via Stimulating SNHG16/miR-212-3p and linc00667/miR-429 Axis

机译：击倒USF1通过刺激SNHG16 / miR-212-3p和linc00667 / miR-429轴抑制胶质瘤细胞的血管生成模仿
- 作者：Di Wang;Jian Zheng;Xiaobai Liu;Yixue Xue;Libo Liu;Jun Ma;Qianru He;Zhen Li;Heng Cai;Yunhui Liu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- USF1 SNHG16 linc00667 miR-212-3p miR-429 ALDH1A1 glioma;
28.Drug Resistance-Related Competing Interactions of lncRNA and mRNA across 19 Cancer Types

机译：跨越19种癌症类型的lncRNA和mRNA的耐药相关竞争相互作用
- 作者：Haizhou Liu;Shuyuan Wang;Shunheng Zhou;Qianqian Meng;Xueyan Ma;Xiaofeng Song;Lihong Wang;Wei Jiang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- drug resistance pan-cancer pan-drug ceRNA network module lncRNA;
29.Exosomal Transmission of MicroRNA from HCV Replicating Cells Stimulates Transdifferentiation in Hepatic Stellate Cells

机译：从HCV复制细胞的微小RNA的体外传递刺激肝星状细胞中的转分化。
- 作者：Ji Hyun Kim;Chang Ho Lee;Seong-Wook Lee
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- hepatitis C virus liver fibrosis hepatic stellate cells hepatocytes exosome microRNA miR-192 transdifferentiation myofibroblasts fibrogenic marker;
30.Influence of a 3′ Terminal Ribozyme on AgoshRNA Biogenesis and Activity

机译：3末端核酶对AgoshRNA生物发生和活性的影响
- 作者：Elena Herrera-Carrillo;Zongliang Gao;Ben Berkhout
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- HIV RNAi Dicer Ago2 ribozyme Dicer-independent shRNA miR-451;
31.Bioengineered Let-7c Inhibits Orthotopic Hepatocellular Carcinoma and Improves Overall Survival with Minimal Immunogenicity

机译：生物工程的Let-7c抑制原位肝细胞癌并以最小的免疫原性提高总体存活率
- 作者：Joseph L. Jilek;Qian-Yu Zhang;Mei-Juan Tu;Pui Yan Ho;Zhijian Duan;Jing-Xin Qiu;Ai-Ming Yu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA bioengineering hepatocellular carcinoma lipopolyplex xenograft;
32.iPseU-CNN: Identifying RNA Pseudouridine Sites Using Convolutional Neural Networks

机译：iPseU-CNN：使用卷积神经网络识别RNA假尿苷位点
- 作者：Muhammad Tahir;Hilal Tayara;Kil To Chong
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- convolution neural network deep learning iPseU-CNN pseudouridine sites RNA;
33.The Downregulation of MicroRNA hsa-miR-340-5p in IAV-Infected A549 Cells Suppresses Viral Replication by Targeting RIG-I and OAS2

机译：IAV感染的A549细胞中MicroRNA hsa-miR-340-5p的下调通过靶向RIG-1和OAS2抑制病毒复制。
- 作者：Lianzhong Zhao;Xiaohan Zhang;Zhu Wu;Kun Huang;Xiaomei Sun;Huanchun Chen;Meilin Jin
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA miR340 RIG-I antiviral response influenza A virus;
34.miR-31-5p Is a Potential Circulating Biomarker and Therapeutic Target for Oral Cancer

机译：miR-31-5p是口腔癌的潜在循环生物标志物和治疗靶标
- 作者：Zhiyuan Lu;Qianting He;Jianfeng Liang;Wuguo Li;Qiao Su;Zujian Chen;Quan Wan;Xiaofeng Zhou;Laurel Cao;Jingjing Sun;Yu Wu;Lin Liu;Xinming Wu;Jinsong Hou;Keqian Lian;Anxun Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- oral cancer biomarker circulating miRNA miR-31-5p target therapy;
35.Scavenger Receptor Class A1 Mediates Uptake of Morpholino Antisense Oligonucleotide into Dystrophic Skeletal Muscle

机译：清道夫受体A1类介导Morpholino反义寡核苷酸摄取到营养不良的骨骼肌中。
- 作者：Shouta Miyatake;Yoshitaka Mizobe;Maria K. Tsoumpra;Kenji Rowel Q. Lim;Yuko Hara;Fazel Shabanpoor;Toshifumi Yokota;Shin’ichi Takeda;Yoshitsugu Aoki
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- phosphorodiamidate morpholino oligomer exon skipping oligonucleotide uptake scavenger receptor zeta potential Duchenne muscular dystrophy endocytosis splice switching mdx52 delivery;
36.Circular RNA SNX29 Sponges miR-744 to Regulate Proliferation and Differentiation of Myoblasts by Activating the Wnt5a/Ca2+ Signaling Pathway

机译：环状RNA SNX29海绵miR-744通过激活Wnt5a / Ca2 +信号通路来调节成肌细胞的增殖和分化
- 作者：Shujun Peng;Chengchuang Song;Hui Li;Xiukai Cao;Yilei Ma;Xiaogang Wang;Yongzhen Huang;Xianyong Lan;Chuzhao Lei;Buren Chaogetu;Hong Chen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- circRNA non-canonical Wnt pathway bovine myogenesis;
37.MicroRNA-672-5p Identified during Weaning Reverses Osteopenia and Sarcopenia in Ovariectomized Mice

机译：断奶期间鉴定的MicroRNA-672-5p逆转了去卵巢小鼠的骨减少症和肌肉减少症
- 作者：Naseer Ahmad;Priyanka Kushwaha;Anirudha Karvande;Ashish Kumar Tripathi;Priyanka Kothari;Sulekha Adhikary;Vikram Khedgikar;Vijay Kumar Mishra;Ritu Trivedi
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA-672-5p trabecular microarchitecture micro-computed tomography osteopenia sarcopenia;
38.Deletion of miR-126a Promotes Hepatic Aging and Inflammation in a Mouse Model of Cholestasis

机译：miR-126a的删除促进胆汁淤积小鼠模型中的肝衰老和炎症。
- 作者：Yi Yan;Dan Qin;Bian Hu;Chunjing Zhang;Shenghui Liu;Dongde Wu;Wendong Huang;Xingxu Huang;Liqiang Wang;Xiangmei Chen;Lisheng Zhang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- aging CRISPR-Cas9 liver miRNA-126a VCAN BMSC transplantation inflammation;
39.ERK Inhibitor Enhances Everolimus Efficacy through the Attenuation of dNTP Pools in Renal Cell Carcinoma

机译：ERK抑制剂通过减少肾细胞癌中dNTP池增强依维莫司的功效
- 作者：Yun Zou;Wenzhi Li;Juan Zhou;Jin Zhang;Yiran Huang;Zhong Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- renal cell carcinoma ERK inhibitor everolimus dNTP ribonucleotide reductase;
40.Enhancing MicroRNA Activity through Increased Endosomal Release Mediated by Nigericin

机译：通过增加尼日菌介导的内体释放来增强MicroRNA活性
- 作者：Esteban A. Orellana;Ahmed M. Abdelaal;Loganathan Rangasamy;Srinivasarao Tenneti;Sunghyun Myoung;Philip S. Low;Andrea L. Kasinski
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA miR-34 nigericin endosomal escape folate ligand delivery folate-conjugates;
41.Circulating lncRNA BC030099 Increases in Preeclampsia Patients

机译：子痫前期患者中循环lncRNA BC030099的增加
- 作者：Yuhong Sun;Yan Hou;Nan Lv;Qian Liu;Nan Lin;Shuyu Zhao;Xiaodan Chu;Xuan Chen;Guobin Cheng;Peiling Li
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- lncRNA biomarker preeclampsia peripheral blood;
42.MicroRNA-3648 Is Upregulated to Suppress TCF21 Resulting in Promotion of Invasion and Metastasis of Human Bladder Cancer

机译：MicroRNA-3648被上调以抑制TCF21从而促进人膀胱癌的侵袭和转移
- 作者：Wenrui Sun;Shi Li;Yuan Yu;Honglei Jin;Qipeng Xie;Xiaohui Hua;Shuai Wang;Zhongxian Tian;Huxiang Zhang;Guosong Jiang;Chuanshu Huang;Haishan Huang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-3648 TCF21 KISS1 bladder cancer metastasis;
43.TFAP2C-Activated MALAT1 Modulates the Chemoresistance of Docetaxel-Resistant Lung Adenocarcinoma Cells

机译：TFAP2C激活的MALAT1调节多西他赛耐药的肺腺癌细胞的化学耐药性。
- 作者：Jing Chen;Xiaobei Liu;Yichen Xu;Kai Zhang;Jiayuan Huang;Banzhou Pan;Dongqin Chen;Shiyun Cui;Haizhu Song;Rui Wang;Xiaoyuan Chu;Xiaoli Zhu;Longbang Chen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- MALAT1 miR-200b LUAD chemoresistance;
44.MicroRNA-146b Overexpression Promotes Human Bladder Cancer Invasion via Enhancing ETS2-Mediated mmp2 mRNA Transcription

机译：MicroRNA-146b过表达通过增强ETS2介导的mmp2 mRNA转录来促进人类膀胱癌侵袭。
- 作者：Junlan Zhu;Chunxia Xu;Liming Ruan;Jianping Wu;Yang Li;Xingguo Zhang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-146b human bladder cancer invasion MMP2 AUF1 ETS2;
45.miR-223 Regulates Cell Proliferation and Invasion via Targeting PDS5B in Pancreatic Cancer Cells

机译：miR-223通过靶向胰腺癌细胞中的PDS5B调节细胞增殖和侵袭
- 作者：Jia Ma;Tong Cao;Yue Cui;Fan Zhang;Ying Shi;Jun Xia;Z. Peter Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-223 PDS5B growth invasion pancreatic cancer;
46.Long Noncoding RNA SBF2-AS1 Is Critical for Tumorigenesis of Early-Stage Lung Adenocarcinoma

机译：长非编码RNA SBF2-AS1对于早期肺腺癌的肿瘤发生至关重要。
- 作者：Rui Chen;Wenjia Xia;Siwei Wang;Youtao Xu;Zhifei Ma;Weizhang Xu;Erbao Zhang;Jie Wang;Tian Fang;Quan’an Zhang;Gaochao Dong;William Chi-shing Cho;Patrick C. Ma;Giovanni Brandi;Simona Tavolari;Peter Ujhazy;Giulio Metro;Helmut H. Popper;Rong Yin;Mantang Qiu;Lin Xu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- WGCNA lung adenocarcinoma tumorigenesis ceRNA SBF2-AS1 lncRNA;
47.Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients

机译：靶向C9orf72的人工MicroRNA可以减少ALS和FTD患者的核内转录本积累
- 作者：Raygene Martier;Jolanda M. Liefhebber;Jana Miniarikova;Tom van der Zon;Jolanda Snapper;Iris Kolder;Harald Petry;Sander J. van Deventer;Melvin M. Evers;Pavlina Konstantinova
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- C9orf72 ALS FTD gene therapy microRNA;
48.Regulatory Network of Two Tumor-Suppressive Noncoding RNAs Interferes with the Growth and Metastasis of Renal Cell Carcinoma

机译：两种抑制肿瘤的非编码RNA的调控网络干扰肾细胞癌的生长和转移。
- 作者：Hui Zhou;Kun Tang;Haoran Liu;Jin Zeng;Heng Li;Libin Yan;Junhui Hu;Wei Guan;Ke Chen;Hua Xu;Zhangqun Ye
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-124 MEG3 methylation p53 renal cell carcinoma EZH2 PTPN11 noncoding RNA;
49.circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1

机译：cibc RAPGEF5通过调节miR-198 / FGFR1促进乳头状甲状腺的增殖和转移
- 作者：Weiwei Liu;Ji Zhao;Mingming Jin;Ming Zhou
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- circRNA RAPGEF5 papillary thyroid cancer miR-198 FGFR1 sponging;
50.Prediction of Potential Disease-Associated MicroRNAs by Using Neural Networks

机译：使用神经网络预测潜在的疾病相关MicroRNA。
- 作者：Xiangxiang Zeng;Wen Wang;Gaoshan Deng;Jiaxin Bing;Quan Zou
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- disease disease similarity miRNAs miRNA-disease association neural network;
51.FOXM1-Mediated LINC-ROR Regulates the Proliferation and Sensitivity to Sorafenib in Hepatocellular Carcinoma

机译：FOXM1介导的LINC-ROR调节肝细胞癌中索拉非尼的增殖和敏感性。
- 作者：Yingru Zhi;Mubalake Abudoureyimu;Hao Zhou;Ting Wang;Bing Feng;Rui Wang;Xiaoyuan Chu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- LINC-ROR FOXM1 miR-876-5p HCC sorafenib sensitivity;
52.Emerging Epigenetic Regulation of Circular RNAs in Human Cancer

机译：人类癌症中环状RNA的表观遗传调控。
- 作者：Jie Wu;Xiaoqian Qi;Lina Liu;Xin Hu;Jingwen Liu;Jianming Yang;Jun Yang;Lu Lu;Zheng Zhang;Shiqing Ma;Hongfa Li;Xinyue Yun;Tong Sun;Yue Wang;Zuomin Wang;Zihao Liu;Wei Zhao
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- circRNA cancer biomarker epigenetics biogenesis;
53.Synthetic Design of Asymmetric miRNA with an Engineered 3′ Overhang to Improve Strand Selection

机译：具有工程3突出端的不对称miRNA的合成设计以改善链选择
- 作者：Sandeep Kadekar;Ganesh N. Nawale;Kira Karlsson;Cecilia Ålander;Oommen P. Oommen;Oommen P. Varghese
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- RNAi miRNA miR34a strand selection anticancer therapy;
54.lncRNA HIF1A Antisense RNA 2 Modulates Trophoblast Cell Invasion and Proliferation through Upregulating PHLDA1 Expression

机译：lncRNA HIF1A反义RNA 2通过上调PHLDA1表达来调节滋养细胞侵袭和增殖
- 作者：Dan Wu;Nana Yang;Yetao Xu;Sailan Wang;Yuanyuan Zhang;Matthew Sagnelli;Bingqing Hui;Zhenyao Huang;Lizhou Sun
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- preeclampsia HIF1A-AS2 LSD1 proliferation invasion PHLDA1;
55.Targeted SHP-1 Silencing Modulates the Macrophage Phenotype Leading to Metabolic Improvement in Dietary Obese Mice

机译：有针对性的SHP-1沉默调节巨噬细胞表型导致饮食性肥胖小鼠的代谢改善。
- 作者：Yadhu Sharma;Altaf Ahmad;Prabhu Srinivas Yavvari;Sandeep Kumar Muwal;Avinash Bajaj;Farah Khan
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- glucan particles targeted delivery adipose tissue macrophage obesity SHP-1 siRNA;
56.Targeted Transgene Activation in the Brain Tissue by Systemic Delivery of Engineered AAV1 Expressing CRISPRa

机译：通过基因工程表达AAV1的CRISPRa的系统递送在脑组织中靶向转基因激活
- 作者：Cia-Hin Lau;Jonathan Weng-Thim Ho;Pik Kwan Lo;Chung Tin
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- AAV capsid adeno-associated virus cis-regulatory elements CRISPR activation CRISPR interference brain delivery;
57.Targeting Lymph Node Sinus Macrophages to Inhibit Lymph Node Metastasis

机译：靶向淋巴结窦巨噬细胞抑制淋巴结转移
- 作者：Junqing Hu;Jinhao Xu;Mingyue Li;Yanping Zhang;Huaiqiang Yi;Jiangning Chen;Lei Dong;Junfeng Zhang;Zhen Huang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- lymph node sinus macrophages lymph node metastasis cancer immunotherapy;
58.Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice

机译：氨基糖苷增强反义吗啉寡核苷酸在体外和mdx小鼠中的递送
- 作者：Mingxing Wang;Bo Wu;Sapana N. Shah;Peijuan Lu;Qilong Lu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- aminoglycoside antisense delivery exon skipping PMO muscular dystrophy;
59.miR-150-5p Inhibits Non-Small-Cell Lung Cancer Metastasis and Recurrence by Targeting HMGA2 and β-Catenin Signaling

机译：miR-150-5p通过靶向HMGA2和β-Catenin信号传导抑制非小细胞肺癌的转移和复发
- 作者：Fu-Qiang Dai;Cheng-Run Li;Xiao-Qing Fan;Long Tan;Ren-Tao Wang;Hua Jin
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-150-5p cancer stem cell metastasis recurrence NSCLC;
60.Anti-Niemann Pick C1 Single-Stranded Oligonucleotides with Locked Nucleic Acids Potently Reduce Ebola Virus Infection In Vitro

机译：带有锁定核酸的抗Niemann Pick C1单链寡核苷酸可有效减少埃博拉病毒的体外感染
- 作者：Anne Sadewasser;Erik Dietzel;Sven Michel;Michael Klüver;Markus Helfer;Tamara Thelemann;Richard Klar;Markus Eickmann;Stephan Becker;Frank Jaschinski
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- Ebola virus antisense oligonucleotide NPC1 LNA;
61.Characterization of G-Quadruplex Motifs in espB espK and cyp51 Genes of Mycobacterium tuberculosis as Potential Drug Targets

机译：结核分枝杆菌的espBespK和cyp51基因中的G-四联体基序表征为潜在的药物靶标
- 作者：Subodh Kumar Mishra;Uma Shankar;Neha Jain;Kriti Sikri;Jaya Sivaswami Tyagi;Tarun Kumar Sharma;Jean-Louis Mergny;Amit Kumar
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- G-quadruplex Mycobacterium tuberculosis drug targets anti-tuberculosis compounds G-quadruplex mediated inhibition G-quadruplex binder;
62.A Novel lncRNA IHS Promotes Tumor Proliferation and Metastasis in HCC by Regulating the ERK- and AKT/GSK-3β-Signaling Pathways

机译：新型lncRNA IHS通过调节ERK和AKT /GSK-3β信号通路促进肝癌的肿瘤增殖和转移
- 作者：Zheng Chen;Wei Yu;Qiming Zhou;Jianlong Zhang;Hai Jiang;Dake Hao;Jie Wang;Zhenyu Zhou;Chuanchao He;Zhiyu Xiao
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- hepatocellular carcinoma SMYD3 lncRNA-HIS DUSP5 DUSP10 MAP3K8 ERK AKT metastasis proliferation;
63.MicroRNA-1305 Inhibits the Stemness of LCSCs and Tumorigenesis by Repressing the UBE2T-Dependent Akt-Signaling Pathway

机译：MicroRNA-1305通过抑制UBE2T依赖的Akt信号通路抑制LCSCs的茎和肿瘤发生。
- 作者：Xiaoyong Wei;Xiaolong You;Jianlong Zhang;Cuncai Zhou
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA-1305 ubiquitin-conjugating enzyme E2T Akt-signaling pathway liver cancer stem cells hepatocellular carcinoma self-renewal stemness tumorigenicity;
64.Meta-4mCpred: A Sequence-Based Meta-Predictor for Accurate DNA 4mC Site Prediction Using Effective Feature Representation

机译：Meta-4mCpred：基于序列的Meta预测因子可使用有效特征表示进行准确的DNA 4mC位点预测
- 作者：Balachandran Manavalan;Shaherin Basith;Tae Hwan Shin;Leyi Wei;Gwang Lee
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- DNA N4-methylcytosine feature representation learning probabilistic features support vector machine meta-predictor;
65.miR-133b Downregulation Reduces Vulnerable Plaque Formation in Mice with AS through Inhibiting Macrophage Immune Responses

机译：miR-133b下调通过抑制巨噬细胞的免疫反应减少了AS小鼠的易损斑块形成
- 作者：Cheng-Gen Zheng;Bing-Yu Chen;Ren-Hua Sun;Xiao-Zhou Mou;Fang Han;Qian Li;Hai-Jun Huang;Jing-Quan Liu;Yue-Xing Tu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- microRNA-133b atherosclerosis Notch-signaling pathway macrophage plaque formation;
66.miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression

机译：miR-455-3p通过抑制HSF1表达来减轻肝星状细胞活化和肝纤维化
- 作者：Song Wei;Qi Wang;Haoming Zhou;Jiannan Qiu;Changyong Li;Chengyu Shi;Shun Zhou;Rui Liu;Ling Lu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- miR-455-3p HSF1 hepatic stellate cells liver fibrosis;
67.Thioflavin T Monitoring of Guanine Quadruplex Formation in the rs689-Dependent INS Intron 1

机译：硫黄素T监测rs689依赖的INS内含子1中鸟嘌呤四链体形成。
- 作者：Ana Lages;Christopher G. Proud;John W. Holloway;Igor Vorechovsky
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- type 1 diabetes proinsulin gene 3′ splice site polymorphism G quadruplex transcription;
68.Exosomes from Microglia Attenuate Photoreceptor Injury and Neovascularization in an Animal Model of Retinopathy of Prematurity

机译：小胶质细胞外泌体减轻早产儿视网膜病变动物模型中的感光细胞损伤和新生血管形成。
- 作者：Wenqin Xu;Ying Wu;Zhicha Hu;Lijuan Sun;Guorui Dou;Zifeng Zhang;Haiyang Wang;Changmei Guo;Yusheng Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- exosomes microglial cells miR-24-3p oxygen-induced retinopathy retinopathy of prematurity;
69.Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer

机译：外泌体微小RNA在癌症中的新兴功能及其临床价值
- 作者：Man Wang;Fei Yu;Han Ding;Yu Wang;Peifeng Li;Kun Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- exosome microRNA carcinogenesis cancer pathogenesis cancer biomarker cancer diagnosis cancer treatment;
70.circIFT80 Functions as a ceRNA of miR-1236-3p to Promote Colorectal Cancer Progression

机译：circIFT80作为miR-1236-3p的ceRNA促进结直肠癌的进展
- 作者：Wenming Feng;Hui Gong;Yongchun Wang;Guoliang Zhu;Tao Xue;Yao Wang;Ge Cui
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- CRC exosome circRNAs circIFT80 ceRNA HOXB7;
71.Blocking lncRNA MALAT1/miR-199a/ZHX1 Axis Inhibits Glioblastoma Proliferation and Progression

机译：阻断lncRNA MALAT1 / miR-199a / ZHX1轴抑制胶质母细胞瘤的增殖和进程
- 作者：Keman Liao;Yingying Lin;Weizhen Gao;Zhipeng Xiao;Rogelio Medina;Pauline Dmitriev;Jing Cui;Zhengping Zhuang;Xiaochun Zhao;Yongming Qiu;Xiaohua Zhang;Jianwei Ge;Liemei Guo
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2019年第-1期
- MALAT1 ZHX1 glioblastoma competing endogenous RNA long non-coding RNA;
72.METTL3 Facilitates Oral Squamous Cell Carcinoma Tumorigenesis by Enhancing c-Myc Stability via YTHDF1-Mediated m6A Modification

机译：METTL3通过YTHDF1介导的m6A修饰增强c-Myc稳定性促进口腔鳞状细胞癌的肿瘤发生。
- 作者：Wei Zhao;Yameng Cui;Lina Liu;Xiaozhou Ma;Xiaoqian Qi;Yue Wang;Zihao Liu;Shiqing Ma;Jingwen Liu;Jie Wu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- oral squamous cell carcinoma;
- m;
73.The Processing Gene Regulation Biological Functions and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review

机译：N4-乙酰胞苷对RNA的加工基因调控生物学功能和临床意义：系统评价。
- 作者：Gehui Jin;Mingqing Xu;Mengsha Zou;Shiwei Duan
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- N4-acetylcytidine;
- RNA;
- acetyltransferase;
- NAT10;
- human diseases;
- cancer;
- mRNA modifications;
74.Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC

机译：腺瘤-癌症转变中的综合RNA测序确定了人类CRC的预测生物标记物和治疗靶标。
- 作者：Mingzhe Zhu;Yanqi Dang;Zhenhua Yang;Yang Liu;Li Zhang;Yangxian Xu;Wenjun Zhou;Guang Ji
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
75.Aptamer-Functionalized Drug Nanocarrier Improves Hepatocellular Carcinoma toward Normal by Targeting Neoplastic Hepatocytes

机译：适体功能的药物纳米载体通过靶向肿瘤性肝细胞使肝细胞癌向正常状态发展
- 作者：Samrat Chakraborty;Zewdu Yilma Dlie;Somdyuti Chakraborty;Somdatta Roy;Biswajit Mukherjee;Shila Elizabeth Besra;Saikat Dewanjee;Alankar Mukherjee;Probir Kumar Ojha;Vinay Kumar;Ramkrishna Sen
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- site-specific targeting;
- hepatocarcinogenesis;
- apoptosis;
- mitochondrial-dependent intrinsic pathway;
- molecular modeling;
- TAG-72;
- HSP70;
76.Targeting Circulating SINEs and LINEs with DNase I Provides Metastases Inhibition in Experimental Tumor Models

机译：用DNase I靶向循环SINE和LINE可在实验性肿瘤模型中提供转移抑制
- 作者：Ludmila A. Alekseeva;Aleksandra V. Sen’kova;Marina A. Zenkova;Nadezhda L. Mironova
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- circulating cell-free DNA;
- SINEs;
- LINEs;
- tumor;
- metastasis;
- horizontal transfer;
77.lncRNA KCNQ1OT1 Suppresses the Inflammation and Proliferation of Vascular Smooth Muscle Cells through IκBa in Intimal Hyperplasia

机译：lncRNA KCNQ1OT1通过内膜增生中的IκBa抑制血管平滑肌细胞的炎症和增殖
- 作者：Bozhi Ye;Zi-heng Wu;Tung Yu Tsui;Bao-fu Zhang;Xiang Su;Yi-hui Qiu;Xiang-tao Zheng
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- vascular smooth muscle cells;
- intimal hyperplasia;
- KCNQ1OT1;
- IκBa;
- proliferation;
- inflammation;
- ubiquitination;
- miR221;
- methylation;
78.Dose-Finding Study and Pharmacokinetics Profile of the Novel 13-Mer Antisense miR-221 Inhibitor in Sprague-Dawley Rats

机译：新型13-Mer反义miR-221抑制剂在Sprague-Dawley大鼠中的剂量发现研究和药代动力学概况
- 作者：Maria Teresa Di Martino;Mariamena Arbitrio;Daniele Caracciolo;Francesca Scionti;Pierosandro Tagliaferri;Pierfrancesco Tassone
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- miR-221;
- LNA-i-miR-221;
- non-coding RNAs;
- miRNA therapeutics;
- RNA therapeutics;
- LNA;
- pharmacokinetics;
- toxicity study;
- rat;
- antisense oligonucleotides;
79.Associations of lncRNA H19 Polymorphisms at MicroRNA Binding Sites with Glioma Susceptibility and Prognosis

机译：微小RNA结合位点lncRNA H19多态性与胶质瘤易感性和预后的关系
- 作者：Yujiao Deng;Linghui Zhou;Jia Yao;Yu Liu;Yi Zheng;Si Yang;Ying Wu;Na Li;Peng Xu;Lijuan Lyu;Dai Zhang;Jun Lyu;Zhijun Dai
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- single nucleotide polymorphisms;
- glioma;
- susceptibility;
- prognosis;
80.Long Noncoding RNA RC3H2 Facilitates Cell Proliferation and Invasion by Targeting MicroRNA-101-3p/EZH2 Axis in OSCC

机译：长非编码RNA RC3H2通过在OSCC中靶向MicroRNA-101-3p / EZH2轴促进细胞增殖和侵袭
- 作者：Kun Wu;Yingying Jiang;Wenkai Zhou;Bolin Zhang;Yan Li;Fei Xie;Jianjun Zhang;Xu Wang;Ming Yan;Qin Xu;Zhenhu Ren;Wantao Chen;Wei Cao
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- EZH2;
- lncRNA RC3H2;
- microRNA-101-3p;
- proliferation;
- migration;
- invasion;
- metastasis;
- competitive endogenous RNA;
- oral squamous cell carcinoma;
81.N6-Methyladenosine METTL3 Modulates the Proliferation and Apoptosis of Lens Epithelial Cells in Diabetic Cataract

机译：N6-甲基腺苷METTL3调节糖尿病性白内障晶状体上皮细胞的增殖和凋亡
- 作者：Jun Yang;Jingshu Liu;Shaozhen Zhao;Fang Tian
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- N;
82.lncRNA NEAT1 Binds to MiR-339-5p to Increase HOXA1 and Alleviate Ischemic Brain Damage in Neonatal Mice

机译：lncRNA NEAT1与MiR-339-5p结合以增加HOXA1并减轻新生小鼠的缺血性脑损伤
- 作者：Jing Zhao;Ling He;Lingling Yin
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- ischemic brain damage;
- hypoxic-ischemic brain damage;
- HOXA1;
- NEAT1;
- long non-coding RNA;
- microRNA;
- miR-339-5p;
- neonatal mice;
83.Inferences of Individual Drug Response-Related Long Non-coding RNAs Based on Integrating Multi-omics Data in Breast Cancer

机译：整合多组学数据的乳腺癌个体与药物反应相关的长非编码RNA的推断
- 作者：Hao Cui;Hanqing Kong;Fuhui Peng;Chunjing Wang;Dandan Zhang;Jiawei Tian;Lei Zhang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- breast cancer;
- drug response;
- long non-coding RNAs;
- multi-omics integration;
- prognosis;
84.Aberrant Expression Profiles of lncRNAs and Their Associated Nearby Coding Genes in the Hippocampus of the SAMP8 Mouse Model with AD

机译：在患有AD的SAMP8小鼠模型海马中lncRNA及其相关编码基因的异常表达谱
- 作者：Honghai Hong;Yousheng Mo;Dongli Li;Zhiheng Xu;Yanfang Liao;Ping Yin;Xinning Liu;Yong Xia;Jiansong Fang;Qi Wang;Shuhuan Fang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- lncRNAs;
- lncRNA-associated nearby genes;
- Alzheimer’s disease;
85.Machine Learning of Single-Cell Transcriptome Highly Identifies mRNA Signature by Comparing F-Score Selection with DGE Analysis

机译：单细胞转录组的机器学习通过将F得分选择与DGE分析进行比较来高度识别mRNA签名
- 作者：Pengfei Liang;Wuritu Yang;Xing Chen;Chunshen Long;Lei Zheng;Hanshuang Li;Yongchun Zuo
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- developmental mRNA signature;
- single-cell transcriptome;
- machine learning;
- feature selection;
- prediction;
- differential gene expression;
- DGE;
86.HIF-1α or HOTTIP/CTCF Promotes Head and Neck Squamous Cell Carcinoma Progression and Drug Resistance by Targeting HOXA9

机译：HIF-1α或HOTTIP / CTCF通过靶向HOXA9促进头颈部鳞状细胞癌进展和耐药性
- 作者：Qiang Sun;Shuai-Yuan Zhang;Jun-Fang Zhao;Xin-Guang Han;Hai-Bin Wang;Ming-Lei Sun
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- head and neck squamous cell carcinoma (HNSCC);
- HOXA9;
- HOTTIP;
- CTCF;
87.Targeting Ephrin Receptor Tyrosine Kinase A2 with a Selective Aptamer for Glioblastoma Stem Cells

机译：针对胶质母细胞瘤干细胞的选择性适体靶向Ephrin受体酪氨酸激酶A2。
- 作者：Alessandra Affinito;Cristina Quintavalle;Carla Lucia Esposito;Giuseppina Roscigno;Catello Giordano;Silvia Nuzzo;Lucia Ricci-Vitiani;Iolanda Scognamiglio;Zoran Minic;Roberto Pallini;Maxim V. Berezovski;Vittorio de Francisis;Gerolama Condorelli
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- glioblastoma;
- cancer stem cell;
- aptamer;
- EphA2;
- GSCs;
- RNA;
- cancer therapy;
- therapeutic RNAs;
88.Tumor-Suppressive MicroRNA-216b Binds to TPX2 Activating the p53 Signaling in Human Cutaneous Squamous Cell Carcinoma

机译：肿瘤抑制MicroRNA 216b绑定到TPX2激活人类皮肤鳞状细胞癌中的p53信号传导。
- 作者：Cheng Feng;Hai-Lin Zhang;Ang Zeng;Ming Bai;Xiao-Jun Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- microRNA-216b;
- TPX2;
- p53 signaling;
- human cutaneous squamous cell carcinoma;
- proliferation;
- invasion;
- migration;
- apoptosis;
89.Robustness of Catalytically Dead Cas9 Activators in Human Pluripotent and Mesenchymal Stem Cells

机译：人多能和间充质干细胞中催化死Cas9激活剂的稳健性。
- 作者：Paolo Petazzi;Raul Torres-Ruiz;Antonella Fidanza;Heleia Roca-Ho;Francisco Gutierrez-Agüera;Julio Castaño;Sandra Rodriguez-Perales;Rafael Díaz de la Guardia;Belén López-Millán;Anna Bigas;Lesley M. Forrester;Clara Bueno;Pablo Menéndez
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- dCas9 activators;
- SAM;
- SunTag;
- hPSCs;
- hMSCs;
- CRISPR;
90.lncRNA PVT1/MicroRNA-17-5p/PTEN Axis Regulates Secretion of E2 and P4 Proliferation and Apoptosis of Ovarian Granulosa Cells in PCOS

机译：lncRNA PVT1 / MicroRNA-17-5p / PTEN轴调节PCOS中卵巢颗粒细胞E2和P4的分泌增殖和凋亡
- 作者：Gelin Liu;Shengxian Liu;Guanlin Xing;Fang Wang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- long non-coding RNA PVT1;
- microRNA-17-5p;
- PTEN;
- polycystic ovary syndrome;
- ovarian granulosa cells;
- apoptosis;
- proliferation;
- migration;
- invasion;
91.ube3d a New Gene Associated with Age-Related Macular Degeneration Induces Functional Changes in Both In Vivo and In Vitro Studies

机译：ube3d是一种与年龄相关的黄斑变性相关的新基因可在体内和体外研究中诱导功能改变
- 作者：Huika Xia;Qi Zhang;Yan Shen;Yujing Bai;Xiaoyun Ma;Bo Zhang;Yun Qi;Jingjing Zhang;Qinrui Hu;Wei Du;Li Zhu;Peng Zhou;Bin Wang;Hui Xu;Lvzhen Huang;Xiaoxin Li
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- ubiquitin protein ligase E3D;
- age-related macular degeneration;
- zebrafish;
- autophagy;
- oxidative damage;
92.lncRNA KLF3-AS1 Suppresses Cell Migration and Invasion in ESCC by Impairing miR-185-5p-Targeted KLF3 Inhibition

机译：lncRNA KLF3-AS1通过损害miR-185-5p靶向的KLF3抑制来抑制ESCC中的细胞迁移和侵袭
- 作者：Jun-Qi Liu;Ming Deng;Nan-Nan Xue;Ting-Xuan Li;Yue-Xin Guo;Liang Gao;Di Zhao;Rui-Tai Fan
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
93.Osteopontin Upregulates Col IV Expression by Repressing miR-29a in Human Retinal Capillary Endothelial Cells

机译：骨桥蛋白通过抑制人类视网膜毛细血管内皮细胞中的miR-29a上调Col IV表达。
- 作者：Ping Duan;Siyu Chen;Yuxiao Zeng;Haiwei Xu;Yong Liu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- osteopontin;
- retinal capillary endothelial cells;
- diabetic retinopathy;
- collagen type IV;
- miR-29a;
94.hsa_circ_001653 Implicates in the Development of Pancreatic Ductal Adenocarcinoma by Regulating MicroRNA-377-Mediated HOXC6 Axis

机译：hsa_circ_001653通过调节MicroRNA-377介导的HOXC6轴参与胰腺导管腺癌的发展
- 作者：Xiangliang Zhang;Hui Li;Tiantian Zhen;Yu Dong;Xiaojuan Pei;Huijuan Shi
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- pancreatic ductal adenocarcinoma;
- circular RNA;
- hsa_circ_001653;
- microRNA-377;
- HOXC6;
95.MCM3AP-AS1 KD Inhibits Proliferation Invasion and Migration of PCa Cells via DNMT1/DNMT3 (A/B) Methylation-Mediated Upregulation of NPY1R

机译：MCM3AP-AS1 KD通过DNMT1 / DNMT3（A / B）甲基化介导的NPY1R抑制PCa细胞的增殖侵袭和迁移
- 作者：Xin Li;Jiancheng Lv;Shuai Liu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- long non-coding RNA MCM3AP-AS1;
- neuropeptide Y receptor Y1;
- methylation;
- MAPK pathway;
- prostate cancer;
- proliferation;
- migration;
- invasion;
96.Upregulation of OIP5-AS1 Predicts Poor Prognosis and Contributes to Thyroid Cancer Cell Proliferation and Migration

机译：OIP5-AS1的上调可预测不良预后并有助于甲状腺癌细胞的增殖和迁移
- 作者：Qiuli Li;Weichao Chen;Rongzhen Luo;Zhiyi Zhang;Ming Song;Wenkuan Chen;Zhongyuan Yang;Yuanzhong Yang;Zhuming Guo;Ankui Yang
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- OIP5-AS1;
- Wnt/β-catenin signaling;
- proliferation;
- migration;
- thyroid cancer;
97.mmu_circ_

机译：mmu_circ_
- 作者：Lei Yang;Huan Liang;Xianguo Meng;Li Shen;Zhanjiang Guan;Bingchang Hei;Haitao Yu;Shanshan Qi
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- mmu_circ_0000790;
- microRNA-374c;
- FOXC1;
- pulmonary artery smooth muscle cells;
- hypoxic pulmonary hypertension;
- Notch pathway;
98.circRNA-AKT1 Sequesters miR-942-5p to Upregulate AKT1 and Promote Cervical Cancer Progression

机译：circRNA-AKT1隔离miR-942-5p以上调AKT1并促进宫颈癌的进展
- 作者：Rongying Ou;Laiming Mo;Huijing Tang;Shaolong Leng;Haiyan Zhu;Liang Zhao;Yi Ren;Yunsheng Xu
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- circ-AKT1;
- miR-942-5p;
- AKT1;
- cervical cancer;
99.sgRNA-PSM: Predict sgRNAs On-Target Activity Based on Position-Specific Mismatch

机译：sgRNA-PSM：基于特定位置的不匹配预测sgRNA的靶向活性
- 作者：Bin Liu;Zhihua Luo;Juan He
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- sgRNAs on-target activity;
- position-specific mismatch;
- XGBoost;
100.Silencing lncRNA AGAP2-AS1 Upregulates miR-195-5p to Repress Migration and Invasion of EC Cells via the Decrease of FOSL1 Expression

机译：沉默lncRNA AGAP2-AS1通过降低FOSL1表达来上调miR-195-5p以抑制EC细胞的迁移和侵袭
- 作者：Sining Shen;Ke Li;Ying Liu;Xianben Liu;Baoxing Liu;Yufeng Ba;Wenqun Xing
- 期刊名称：《Molecular Therapy. Nucleic Acids》 | 2020年第-1期
- esophageal cancer;
- long non-coding AGAP2-AS1;
- microRNA-195-5p;
- FOSL1;
- proliferation;
- migration;
- invasion;
- apoptosis;