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Pigmented Purpuric Dermatosis: Clinicopathologic Characterization in a Pediatric Series

机译:色素性紫癜性皮肤病:儿科系列的临床病理特征

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Pigmentary purpuras (PPs) are a group of chronic disorders of unknown origin seldom described in children. With this study we sought to better characterize PP eruptions, including clinical evolution and management. A retrospective chart review from 2003 to 2013 querying characteristics of children with a biopsy-proven diagnosis of PP in the Centre Hospitalier Universitaire Ste-Justine dermatology clinic (Montreal, Quebec, Canada) was performed. Follow-up was obtained through telephone interviews. Descriptive statistical analysis was used. Of the 17 subjects, 8 were male and the mean age of onset was 9years. PP was asymptomatic in 11 patients, pruritic in 3, and of cosmetic concern in 3. Schamberg's disease was the most frequent subtype in 12 cases. Resolution of PP was found in 13 cases with a median duration of less than 1 year (range 6months-9years). Five patients experienced spontaneous clearing without treatment, and improvement was observed in 75% of cases treated with topical corticosteroids and 100% with narrowband ultraviolet B (nbUVB). No associated disease, significant drug exposure, or contact allergens were found. Those findings support that PPs in children are idiopathic, chronic eruptions that can benefit from watchful waiting, although topical corticosteroids or nbUVB are may be useful if the patient or family desires faster resolution. This study was limited by its small size, its retrospective nature, and selection and recall bias.
机译:色素性紫癜(PPs)是一类在儿童中很少描述的未知来源的慢性疾病。通过这项研究,我们试图更好地描述PP爆发的特征,包括临床演变和管理。进行了回顾性图表审查,从2003年至2013年在中心医院的University Ste-Justine皮肤病学诊所(蒙特利尔,加拿大魁北克)对经活检证实为PP的儿童的特征进行了查询。通过电话采访获得了随访。使用描述性统计分析。在17名受试者中,有8名是男性,平均发病年龄为9岁。 PP无症状11例,瘙痒3例,美容3例。Schamberg病是12例中最常见的亚型。在13例中位病程少于1年(范围为6个月至9年)的病例中发现了PP消退。五名患者未经治疗自发清除,局部用皮质类固醇激素治疗的患者中有75%发生改善,而窄带紫外线B(nbUVB)患者则有100%出现自发性清除。未发现相关疾病,大量药物暴露或接触过敏原。这些发现支持儿童的PPs是特发性的慢性发作,可以通过观察等待而受益,尽管如果患者或家人希望更快地解决问题,局部使用糖皮质激素或nbUVB可能会有用。这项研究的局限性在于其规模小,回顾性以及选择和回忆偏见。

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