BPOLD: errors in incidence?

摘要

To the Editor:Registries such as British Paediatric Orphan Lung Disease (BPOLD) offer considerable potential for both improving our understanding of disease incidence and also fostering interest in these conditions. BPOLD's recent publication is significant, however, I believe there are systematic errors in their calculation of incidence. Assuming a United Kingdom under 16-year-old population of ~12 million children the incidence figures should be ~l/10th of those quoted (Table 1, page 452). For example, 23 (unconfirmed) cases of "bronchiectasis of unknown cause" were reported in the 12-month period. The annual incidence should therefore be approximately 0.2 (rather than the 2.1 quoted) per 100,000 under 16-year olds.