Highly enantioselective three-component reactions of tert -butyl diazoacetate with arylamines and imines: An efficient synthesis of ??,??-Bis(arylamino) Acid Derivatives

摘要

Enantioselective three-component reactions of tert-butyl diazoacetate with arylamines and imines afford ??,??-bis(arylamino) acid derivatives in good yields (56-90%) with high diastereoselectivities (up to >95:5 dr) and excellent enantioselectivities (up to 96% ee). ? Georg Thieme Verlag Stuttgart ?? New York.