Synthesis of Isoindolo[2,1-a]quinazoline, Isoindolo[2,1-a] pyrrolo [2,1-c]quinoxalinone, and Indolo[1,2-a]isoindolo[1,2-c]quinoxalinone Derivatives in a Deep Eutectic Solvent

摘要

2-Formylbenzoic acid reacts with various derivatives of 2-aminobenzamide, 2-(1H-pyrrol-1-yl) aniline or 2-(1H-indol-1-yl) aniline in a deep eutectic solvent to give the corresponding derivatives of 6,6a-dihydroisoindolo[2,1-a] quinazoline-5,11-dione, isoindolo[2,1a] pyrrolo[2,1-c] quinoxalin-10(14bH)-one, and indolo[1,2-a] isoindolo[1,2-c] quinoxalin-11(15bH)-one, respectively. This protocol is operationally simple, mild, and efficient.