SEMIPARAMETRIC MAXIMUM LIKELIHOOD INFERENCE FOR TRUNCATED OR BIASED-SAMPLING DATA

摘要

Sample selection bias has long been recognized in many fields including clinical trials, epidemiology studies, genome-wide association studies, and wildlife management. This paper investigates the maximum likelihood estimation for censored survival data with selection bias under the Cox regression models where the selection process is modeled parametrically. A novel expectation-maximization algorithm is proposed and shown to have considerable computational advantages. Rigorous asymptotic properties of the estimator are established. Extensive simulation studies and a data analysis are conducted to investigate the performance of the proposed estimation procedure.