Letter to the Editor

摘要

We read with great interest "Recommendations of the National Football League Physician Society Task Force on the Use of Toradol? Ketorolac in the National Football League" by Matthew Matava et al in your September/October 2012 issue.5 We support the recommendations of the task force that ketorolac should be administered only under the direct supervision and order of a team physician and should not be used prophylactically. However, as the developers of the intranasal formulation SPRIX? (ketorolac tromethamine nasal spray),8 we wish to point out some additional published data regarding the pharmacokinetics of the oral formulation as compared with the intranasal formulation. This additional information suggests that oral ketorolac is absorbed more slowly after eating a meal as compared with after a 12-hour fast and suggests that parenteral forms (including intranasal) will be absorbed more rapidly than the oral formulation in a patient who has not fasted recently.