NMR metabolomics 2/2 Multivariate analysis for diagnostic study of streptozotocin-induced diabetes using rat urine

摘要

Assessment and evaluation of physical condition by non-invasive way is highly required to detect complications in a diabetes patient.We tried very early detection of nephritis in diabetes model rats by using NMR metabolic profiling method (NMR-MP).Twenty male Wistar rats (11 week old)were used for the study and their left kidneys were surgically removed and then critical amount of streptozotocin was injected as citrate buffer solution and fed separately in metabolic cages under controlled condition.