Estimating Transcriptome from Genome:a Thermodynamic Approach

摘要

Decoding genomic information is routine work for a cell,but is a challenging theme for researchers.Indeed,although genome sequences have been determined for many organisms,and transcriptomes has been measured under various conditions,genomes cannot be interpreted by means of transcriptomes,and transcriptomes are still not predictable from genome sequences.These problems base on our ignorance on the "grammar"of the genome;i.e.,how quantitative information is embodied in it.