Molecular cloning and sequencing of a novel human P2 nucleotide receptor

摘要

A novel human P2 nucleolide receptor has been cloned from a T-cell cDNA library. The predicted ammo acid sequence shows characteristics of a Ci-protein-eoupled receptor, and shares 88% homology with a recently characterised rat P2 nudeolide receptor sequence. Distinctive features include an extremely short cytoplasmic tail with only one putative protein H kinase V phosphoryiulion site. Northern blot analysis revealed a 1.9 kb transcript expressed in the placenta.