Effects of solvent properties on the Soxhlet extraction ofditerpenoid lactones from Andrographis paniculata leaves

摘要

A solid-liquid extraction was performed for the leaves of Andrographis paniculata in order to obtain twobioactive components, andrographolide and deoxyandrographolide. The problem of hydrolysable components and solventremoval difficulties in the conventional extraction led us to study further the effects of solvent properties on the conventionalextraction using Soxhlet method in order to determine the best solvent or solvent mixture for high extraction yield ofA. paniculata. This solvent selection is very important prior to alternative extraction methods since it can be used as a pre-extraction solvent, main solvent, or co-solvent. Based on the yield of extract and andrographolide and deoxyandrographolidecontent, methanol was found to be the best solvent.