Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis

摘要

Objective: Fc-gamma receptors (Fc gamma Rs) have been shown to play a crucial role in cartilage degradation during experimental arthritis. Although most of their effect on cartilage degradation has been attributed to their potential to promote inflammation in the presence of immunoglobulins, activating Fc gamma Rs promote cartilage degeneration in antigen-induced arthritis (AIA) independently of the level of inflammation. This prompted us to investigate, whether Fc gamma Rs may also play a role in osteoarthritis (OA)-related cartilage degradation.