Synthesis of l-substituted-2-thio-(1H)-4-(3-phenylthiocarbamido-1-yl)- 6-(1-substitutedguanidmo-3-yl)-1,2-dihydro-s-triazine

摘要

Novel series of 1 -substituted-2-thio-( 1H)-4-(3-phenylthiocarbamido-1 -yl)-6-(1 -substituted- guanidino-3 -yl)-1,2-dihydro-s-triazine (4a(i) to 4f(ii)) has been obtained by the isomerisation of 2-(l- substitutedguanidino-3-yl)-4-(3-phenyltbiocarbamido-1-yl)-6- substitutedirnino-1,3,5-thiadiazine (3a(i) to 3f(ii)) in presence of ethanolic sodium bicarbonate solution, which have been obtained by basification of their hydrochlorides (2a(i) to 2f(ii)) which are synthesized by the interaction of 1-Formamidino- (N-_substituted-thioamido)-5-phenyl-2-thio-4-iminobiuret (la-f) and N-aryl/alkyliso-cyanodichlorides. The latter were prepared initially by the condensation of N-aryl/alkylisothiocyanate with N-phenylfornmmidinoformamidinothiocar-bamide. The structure of all these compounds was established on the basis of elemental analysis, IR and PMR spectral data.